Типы материала для пакета блистера в фармацевтической промышленности

В фармацевтической промышленности, Блистерная упаковка является обычным методом упаковки для медицины(особенно таблетки и капсулы). Его основная функция заключается в защите лекарств от воздействия на окружающую среду (такие как кислород, влажность, легкий, и микроорганизмы) во время облегчения хранения и использования. Блистерная упаковка обычно состоит из двух компонентов: базовый материал (который образует волдырь и держит препарат) и материал крышки (which seals the blister).

А Типы пакетных материалов блистера and characteristics are as follows:

I. Blister base material (material that forms the cavity)

The base material must possess good formability (thermoplasticity) and a certain degree of mechanical strength, while also providing various barrier properties (кислород, воды, и свет) depending on the drug’s stability requirements. Общие типы включают:

1. Поливинилхлорид (ПВХ)

– Характеристики: Бюджетный, excellent formability (easily stretched into a blister after heating), and high transparency make it one of the most commonly used base materials.

– Limitations: Poor barrier properties (high oxygen and water vapor transmission), requiring use with other materials or for drugs with high stability.

2. Polyvinylidene chloride (ПВДХ)

– Характеристики: Отличные барьерные свойства (barrier to oxygen, водяной пар, and odors far superior to PVC), good chemical resistance, and outstanding moisture and oxidation resistance.

– Приложения: Often laminated with PVC in the form of a coating (такой как PVC/PVDC composite film), it combines the formability of PVC with the high barrier properties of PVDC and is used for pharmaceuticals requiring high moisture and oxidation resistance (such as tablets and capsules that are prone to moisture absorption).

3. Polyethylene terephthalate (ПЭТ)

– Характеристики: Высокая механическая прочность (impact and tear resistance), good temperature resistance (can withstand high-temperature sterilization), высокая прозрачность, and barrier properties superior to PVC but slightly inferior to PVDC.

– Приложения: Suitable for applications requiring higher strength or temperature resistance. It can also be laminated with other materials (such as PET/PVDC) to further enhance barrier properties.

4. полипропилен (PP)

– Характеристики: Excellent chemical resistance, excellent low-temperature toughness, moderate cost, and barrier properties similar to PVC.

– Приложения: Less commonly used as a standalone substrate, it’s more commonly used in composites with other materials (such as PP/PVDC) or for pharmaceuticals requiring high chemical stability.

5. Cold Forming Aluminum

– Характеристики: Made from multiple layers of aluminum foil (such as aluminum foil/polyethylene), it can be mechanically stamped without heating. It offers exceptional barrier properties (completely blocking oxygen, воды, и свет) and excellent sealing.

– Приложения: Used for pharmaceuticals requiring extremely high stability (such as biologics, highly active drugs, and photosensitive drugs), but the cost is relatively high.

2. Blister Lid Material (Material for Sealing the Blister)

The lid material of blister packaging must possess excellent heat-sealability (tightly bonded to the substrate), be easy to tear (for convenient patient access), and provide a secondary barrier function. Общие типы включают:

1. Pharmaceutical Aluminum Foil

– Состав: Typically 0.02-0.03mm thick pure aluminum foil with a treated surface (one side coated with heat-seal adhesive for heat sealing to the substrate; the other side coated with a printed layer for information labeling).

– Характеристики: Отличные барьерные свойства (кислород, воды, and light barriers) and good sealing, making it the most commonly used lid material.

– Приложения: Suitable for use with substrates such as PVC, ПВХ / ПВДХ, и ПЭТ, it is suitable for most pharmaceuticals.

2. Aluminum-Plastic Composite Film

– Состав: Aluminum foil is laminated with plastic film (such as PE or PET), combining the barrier properties of aluminum foil with the flexibility of plastic.

– Характеристики: Better tearability than pure aluminum foil, suitable for applications requiring easier opening.

3. Paper-Aluminum Composite Film

– Состав: A composite of aluminum foil and paper, with the paper providing stiffness and printability, and the aluminum foil ensuring barrier properties.

– Характеристики: Lower cost, but slightly inferior to pure aluminum foil in barrier properties, making it less suitable for pharmaceuticals requiring high stability.

Выбор types of blister packaging materials should be determined based on a comprehensive consideration of the drug’s stability requirements (such as moisture resistance, устойчивость к окислению, and light protection), cost, and application scenario. ПВХ + pharmaceutical aluminum foil is the most economical and versatile combination. For pharmaceuticals requiring high barrier properties, a PVC/PVDC composite substrate + aluminum foil is often used. Highly sensitive pharmaceuticals often utilize a high-barrier combination of cold-stamped aluminum + алюминиевая фольга.